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Why Are Gly31, Gly33, and Gly35 Highly Conserved in All Fluorescent Proteins?

Biochemistry - 14 Dec 2021

Nwafor Justin, Salguero Christian, Welcome Franceine, Durmus Sercan, Glasser Rachel N, Zimmer Marc, Schneider Tanya L

Abstract excerpt

Green fluorescent protein (GFP)-like fluorescent proteins have been found in more than 120 species. Although the proteins have little sequence identity, Gly31, 33, and 35 are 87, 100, and 95% conserved across all species, respectively. All GFP-like proteins have a β-barrel structure composed of 11 β-sheets, and the 3 conserved glycines are located in the second β-sheet. Molecular dynamics (MD) simulations have...

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Identifiers

PMID: 34806355
DOI: 10.1021/acs.biochem.1c00587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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