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Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

22 Oct 2021

Abstract excerpt

Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic mice reports that accumulated amyloid-β (Aβ) plaques in the retina are toxic to retinal neurons. Moreover, Aβ plaques are deposited around the rods and cones, yet photoreceptor anomalies remain unclear in AD. Here, we identify the...

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PMID: 34805789
DOI: 10.1016/j.isci.2021.103327

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