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Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors

11 Nov 2019

Abstract excerpt

The onset of neurodegenerative diseases activates inflammation that leads to progressive neuronal cell death and impairments in cognition (Alzheimer’s disease) and sight (age-related macular degeneration [AMD]). How neuroinflammation can be counteracted is not known. In AMD, amyloid β-peptide (Aβ) accumulates in subretinal drusen. In the 5xFAD retina, we found early functional deficiencies (ERG) without...

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PMID: 31712409
DOI: 10.1073/pnas.1912959116

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