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Article

Correlation of GSTP1 rs1695 and CAT rs769217 with elevated AST induced by valproate sodium in Chinese children with epilepsy.

Pakistan journal of pharmaceutical sciences - 1 Sept 2021

Wang Linlin, Li Huilan, Zeng Guangting, Shi Lihong, Zhu Miaomiao, Luo Jia, Zhang Zanling

Abstract excerpt

Valproate (VPA)-induced hepatotoxicity is a fatal adverse drug reaction，and children is a high-risk population. Our study aimed to explore whether key genetic polymorphisms of antioxidant pathway is associated with VPA-mediated AST elevation. We included 194 newly diagnosed epilepsy children (aged from 1 to 16 years old) and treated with VPA. These patients were divided into two groups: one group for AST is...

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PMID: 34803013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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