Article
Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes are risk factors for increased serum gamma-glutamyltransferase in valproic acid-treated patients.
Clinica chimica acta; international journal of clinical chemistry - 1 Mar 2008
Fukushima Yumi, Seo Takayuki, Hashimoto Nami, Higa Yoko, Ishitsu Takateru, Nakagawa Kazuko
Abstract excerpt
BACKGROUND: This study was designed to verify whether the glutathione S-transferase (GST) genotypes affect mild hepatotoxicity in valproic acid (VPA)-treated patients. METHODS: The association between the GSTM1 and GSTT1 genotypes, and the levels of aminotransferases and total bilirubin was retro...
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