Article
Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis.
PloS one - 1 Jan 2014
Ogusu Naoki, Saruwatari Junji, Nakashima Hiroo, Noai Madoka, Nishimura Miki, Deguchi Mariko, Oniki Kentaro, Yasui-Furukori Norio, Kaneko Sunao, Ishitsu Takateru, Nakagaswa Kazuko
Abstract excerpt
BACKGROUND: There has been accumulating evidence that there are associations among γ-glutamyltransferase (γ-GT) elevation and all-cause mortality, cardiovascular diseases and metabolic diseases, including nonalcoholic fatty liver disease. The primary objective of this study was to evaluate the impact of the most common and potentially functional polymorphisms of antioxidant enzyme genes, i.e. superoxide dismutase...
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