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Article

Dosing algorithm for Tacrolimus in Tunisian Kidney transplant patients: Effect of CYP 3A41B and CYP3A422 polymorphisms.

Toxicology and applied pharmacology - 15 Nov 2020

Ben-Fredj Nadia, Hannachi Ibtissem, Chadli Zohra, Ben-Romdhane Haifa, A Boughattas Naceur, Ben-Fadhel Najah, Aouam Karim

Abstract excerpt

Prescribing appropriate Tacrolimus (Tac) dosing is still a challenge for clinicians due to the interindividual variability in dose requirement and the narrow therapeutic index. Our objective is to identify potential factors that affects Tac exposure in Tunisian Kidney patients and to develop and validate a Tac dose requirement algorithm including genetic and nongenetic variables. A cross-sectional study was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32949580
DOI: 10.1016/j.taap.2020.115245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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