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Article

Sensitive detection of T790M mutations in lung cancer biopsies using a PCR-based lateral flow assay.

Analytical biochemistry - 15 Jan 2022

Dong Ningning, Wang Wenjia, Lin Shan

Abstract excerpt

T790 M point mutations in EGFR exon 20 are regarded as the most common cause of resistance to epidermal growth factor receptor tyrosine kinase inhibitor treatment. In this study, a PCR-based lateral flow assay (PCR-LFA) was developed to detect T790 M mutations in human genomic DNA. Detection sensitivity was determined using DNA at different mutant to wild-type ratios. The limit of detection of mutant alleles was...

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Identifiers

PMID: 34800430
DOI: 10.1016/j.ab.2021.114476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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