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Article

Multiple epistatic DNA variants in a single gene affect gene expression in trans.

Genetics - 4 Jan 2022

Lutz Sheila, Van Dyke Krisna, Feraru Matthew A, Albert Frank W

Abstract excerpt

DNA variants that alter gene expression in trans are important sources of phenotypic variation. Nevertheless, the identity of trans-acting variants remains poorly understood. Single causal variants in several genes have been reported to affect the expression of numerous distant genes in trans. Whether these simple molecular architectures are representative of trans-acting variation is unknown. Here, we studied...

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Identifiers

PMID: 34791209
DOI: 10.1093/genetics/iyab208
PMCID: PMC8733636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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