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Article

Trans-acting genetic variation affects the expression of adjacent genes.

Genetics - 31 Mar 2021

Van Dyke Krisna, Lutz Sheila, Mekonnen Gemechu, Myers Chad L, Albert Frank W

Abstract excerpt

Gene expression differences among individuals are shaped by trans-acting expression quantitative trait loci (eQTLs). Most trans-eQTLs map to hotspot locations that influence many genes. The molecular mechanisms perturbed by hotspots are often assumed to involve "vertical" cascades of effects in pathways that can ultimately affect the expression of thousands of genes. Here, we report that trans-eQTLs can affect...

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Identifiers

PMID: 33789351
DOI: 10.1093/genetics/iyaa051
PMCID: PMC8611878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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