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Article

Building Endogenous Gene Connections through RNA Self-Assembly Controlled CRISPR/Cas9 Function.

Journal of the American Chemical Society - 1 Dec 2021

Lin Jiao, Wang Wei-Jia, Wang Yang, Liu Yan, Xu Liang

Abstract excerpt

Construction of synthetic circuits that can artificially establish endogenous gene connections is essential to introduce new phenotypes for cellular behaviors. Given the diversity of endogenous genes, it lacks a general and easy-to-design toolbox to manipulate the genetic network. Here we present a type of self-assembly-induced RNA circuit that can directly build regulatory connections between endogenous genes....

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Identifiers

PMID: 34788038
DOI: 10.1021/jacs.1c09041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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