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Expression characteristic of 4Ig B7-H3 and 2Ig B7-H3 in acute myeloid leukemia

17 Nov 2021

Abstract excerpt

4IgB7-H3 (4Ig) and 2IgB7-H3 (2Ig) expression characteristics in acute myeloid leukemia (AML) remain unknown. This study investigated mRNA and membrane protein expression of two B7-H3 isoforms in AML cell lines and de novo patients by using RT-PCR and flow cytometry, and analyzed the B7-H3 promoter methylation state by utilizing RQ-MSP. 4Ig was the dominant isoform. 2Ig mRNA expression rate and abundance were...

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PMID: 34787059
DOI: 10.1080/21655979.2021.2001182

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