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Article

Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia.

Clinical epigenetics - 28 Jan 2021

van Dijk A D, Hoff F W, Qiu Y H, Chandra J, Jabbour E, de Bont E S J M, Horton T M, Kornblau S M

Abstract excerpt

BACKGROUND: Acute leukemia is an epigenetically heterogeneous disease. The intensity of treatment is currently guided by cytogenetic and molecular genetic risk classifications; however these incompletely predict outcomes, requiring additional information for more accurate outcome predictions. We aimed to identify potential prognostic implications of epigenetic modification of histone proteins, with a focus on...

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Share to Antigens, CD34
Share to Epigenomics
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Code

Share to Jumonji Domain-Containing Histone Demethylases

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

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Identifiers

PMID: 33509276
DOI: 10.1186/s13148-021-01011-x
PMCID: PMC7841917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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