Article
Apolipoprotein L1 Gene Effects on Kidney Transplantation.
Seminars in nephrology - 1 Nov 2017
Freedman Barry I, Locke Jayme E, Reeves-Daniel Amber M, Julian Bruce A
Abstract excerpt
The pathogenesis of many common etiologies of nephropathy has been informed by recent molecular genetic breakthroughs. It now is apparent that the ethnic disparity in the risk for nondiabetic chronic kidney disease between African Americans and European Americans is explained largely by variation in the apolipoprotein L1 gene (APOL1). The presence of two APOL1 renal risk variants markedly increases an...
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