Article
Integrating APOL1 Gene Variants Into Renal Transplantation: Considerations Arising From the American Society of Transplantation Expert Conference.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Apr 2017
Newell K A, Formica R N, Gill J S, Schold J D, Allan J S, Covington S H, Wiseman A C, Chandraker A
Abstract excerpt
Thirteen percent of individuals of African ancestry express two variant copies of the gene encoding apolipoprotein 1 (APOL1) that has been associated with an increased risk of end-stage renal disease (ESRD) in the general population. Limited studies suggest that the survival of transplanted kidneys from donors expressing two APOL1 risk alleles is inferior to that of kidneys from donors with zero or one risk...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.