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Dystrophin deficiency affects human astrocyte properties and response to damage

13 Nov 2021

Abstract excerpt

In addition to progressive muscular degeneration due to dystrophin mutations, 1/3 of Duchenne muscular dystrophy (DMD) patients present cognitive deficits. However, there is currently an incomplete understanding about the function of the multiple dystrophin isoforms in human brains. Here, we tested the hypothesis that dystrophin deficiency affects glial function in DMD and could therefore contribute to neural...

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PMID: 34773297
DOI: 10.1002/glia.24116

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