Article

Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes

2021-10-19

Abstract excerpt

<title>Abstract</title> <p>Brain dysfunction in myotonic dystrophy type 1 (DM1), the prototype of toxic RNA disorders, has been mainly attributed to neuronal RNA misprocessing, while little attention has been given to non-neuronal brain cells. Using a transgenic mouse model of DM1 that expresses mutant RNA in various brain cell types, we demonstrate that astrocytes exhibit impaired ramification and polarization i...

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Literature Corpus work: 62c26f61-a9ff-5dd6-a545-4c191250f033
DOI: 10.21203/rs.3.rs-137333/v1

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