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Article

REV1 Inhibition Enhances Radioresistance and Autophagy

21 Oct 2021

Abstract excerpt

Cancer therapy resistance is a persistent clinical challenge. Recently, inhibition of the mutagenic translesion synthesis (TLS) protein REV1 was shown to enhance tumor cell response to chemotherapy by triggering senescence hallmarks. These observations suggest REV1's important role in determining cancer cell response to chemotherapy. Whether REV1 inhibition would similarly sensitize cancer cells to radiation...

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PMID: 34771454
DOI: 10.3390/cancers13215290

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