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Therapeutic interactions of autophagy with radiation and temozolomide in glioblastoma: evidence and issues to resolve

18 Feb 2016

Abstract excerpt

Glioblastoma is a unique model of non-metastasising disease that kills the vast majority of patients through local growth, despite surgery and local irradiation. Glioblastoma cells are resistant to apoptotic stimuli, and their death occurs through autophagy. This review aims to critically present our knowledge regarding the autophagic response of glioblastoma cells to radiation and temozolomide (TMZ) and to...

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PMID: 26889975
DOI: 10.1038/bjc.2016.19

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