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Article

Modulating Glycoside Hydrolase Activity between Hydrolysis and Transfer Reactions Using an Evolutionary Approach.

Molecules (Basel, Switzerland) - 30 Oct 2021

Arreola-Barroso Rodrigo A, Llopiz Alexey, Olvera Leticia, Saab-Rincón Gloria

Abstract excerpt

The proteins within the CAZy glycoside hydrolase family GH13 catalyze the hydrolysis of polysaccharides such as glycogen and starch. Many of these enzymes also perform transglycosylation in various degrees, ranging from secondary to predominant reactions. Identifying structural determinants associated with GH13 family reaction specificity is key to modifying and designing enzymes with increased specificity...

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Identifiers

PMID: 34770995
DOI: 10.3390/molecules26216586
PMCID: PMC8587830

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