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Article

Gly343 mutation enhances gentiobiose conversion efficiency of GH3 family β-glucosidase from Thermotoga maritima STB25.

International journal of biological macromolecules - 1 Feb 2026

Liu Xuan, Li Zexi, Jiang Zihang, Li Zhaofeng, Gu Zhengbiao, Ban Xiaofeng, Hong Yan, Cheng Li, Li Danyang, Li Caiming

Abstract excerpt

Gentiobiose (GEN2) is a low-calorie disaccharide consisting of two glucose units linked via a β-1,6-glycosidic bond. Currently, it is predominantly synthesized by β-glucosidase using glucose as the substrate. However, the low catalytic efficiency of β-glucosidase in gentiobiose synthesis has become a major bottleneck restricting its industrial application. In this study, a rational design strategy was employed to...

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PMID: 41617002
DOI: 10.1016/j.ijbiomac.2026.150555

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