Article
The Role of One-Carbon Metabolism in Schizophrenia and Depression
1 Jul 2007
Abstract excerpt
OBJECTIVE: Physicians often check folate and cobalamin levels in patients with schizophrenia and depression. The reasons for this practice are reviewed, as well as implications for treatment. METHOD: The physiology of the one-carbon cycle, involving folate, cobalamin, homocysteine, S-adenosyl-methionine, and methylene tetrahydrofolate reductase (MTHFR) is first reviewed, and then the particular contributions of...
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