Article

Allosteric Modulation of β1 Integrin Attenuates Motor Asymmetry in the Unilateral 6-Hydroxydopamine Injury Model in Mice

2026-06-23

Abstract excerpt

Parkinson’s disease (PD) is characterised by progressive dopaminergic neurodegeneration in the substantia nigra, leading to debilitating motor dysfunction. Current treatments remain largely symptomatic, highlighting the need for disease-modifying therapies. β1 integrin, implicated in neuroinflammation and trophic signalling, represents a candidate therapeutic target. We investigated whether allosteric β1 integrin...

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Literature Corpus work: 9d479506-9c85-5033-bfca-3f276277d7b1
DOI: 10.64898/2026.06.18.733264

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