Article
Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?
Free radical biology & medicine - 1 Jan 1990
Bandy B, Davison A J
Abstract excerpt
The sensitivity of mitochondrial DNA to damage by mutagens predisposes mitochondria to injury on exposure of cells to genotoxins or oxidative stress. Damage to the mitochondrial genome causing mutations or loss of mitochondrial gene products, or to some nuclear genes encoding mitochondrial membra...
Topics
- Aging
- Animals
- DNA, Mitochondrial
- Humans
- Mitochondria
- Mutation
- Neoplasms
- Oxygen