Article
PMP2/FABP8 induces PI(4,5)P2-dependent transbilayer reorganization of sphingomyelin in the plasma membrane.
Cell reports - 9 Nov 2021
Abe Mitsuhiro, Makino Asami, Murate Motohide, Hullin-Matsuda Françoise, Yanagawa Masataka, Sako Yasushi, Kobayashi Toshihide
Abstract excerpt
Sphingomyelin (SM) is a mammalian lipid mainly distributed in the outer leaflet of the plasma membrane (PM). We show that peripheral myelin protein 2 (PMP2), a member of the fatty-acid-binding protein (FABP) family, can localize at the PM and controls the transbilayer distribution of SM. Genetic screening with genome-wide small hairpin RNA libraries identifies PMP2 as a protein involved in the transbilayer...
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