Impact of Next-generation Sequencing on Interobserver Agreement and Diagnosis of Spitzoid Neoplasms.

doi:10.1097/PAS.0000000000001753

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Article

Impact of Next-generation Sequencing on Interobserver Agreement and Diagnosis of Spitzoid Neoplasms.

The American journal of surgical pathology - 1 Dec 2021

Benton Sarah, Zhao Jeffrey, Zhang Bin, Bahrami Armita, Barnhill Raymond L, Busam Klaus, Cerroni Lorenzo, Cook Martin G, de la Fouchardière Arnaud, Elder David E, Johansson Iva, Landman Gilles, Lazar Alexander, LeBoit Philip, Lowe Lori, Massi Daniela, Duncan Lyn M, Messina Jane, Mihic-Probst Daniela, Mihm Martin C, Piepkorn Michael W, Schmidt Birgitta, Scolyer Richard A, Shea Christopher R, Tetzlaff Michael T, Tron Victor A, Xu Xiaowei, Yeh Iwei, Yun Sook Jung, Zembowicz Artur, Gerami Pedram

Abstract excerpt

Atypical Spitzoid melanocytic tumors are diagnostically challenging. Many studies have suggested various genomic markers to improve classification and prognostication. We aimed to assess whether next-generation sequencing studies using the Tempus xO assay assessing mutations in 1711 cancer-related genes and performing whole transcriptome mRNA sequencing for structural alterations could improve diagnostic...

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PMID: 34757982
DOI: 10.1097/PAS.0000000000001753

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