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Article

Clinical, Morphologic, and Molecular Features of MAP3K8 Rearranged Spitz Neoplasms: A Retrospective Study Documenting That Bonafide Spitz Melanomas Are Rare.

The American journal of surgical pathology - 1 Apr 2024

Patel Pragi, Hagstrom Michael, Sharma Natasha, Chen Alice, Dhillon Soneet, Fumero-Velázquez Mónica, Olivares Shantel, Gerami Pedram

Abstract excerpt

Previous studies regarding the clinical behavior of Spitz neoplasms lack genomic characterization. We aim to assess our hypothesis that most MAP3K8 Spitz neoplasms are indolent despite MAP3K8 being the single most common driver of Spitz melanoma. Further, we aim to identify genomic features associated with aggressive behavior and to better characterize the morphology of these cases. We analyzed the outcomes of...

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Identifiers

PMID: 38233731
DOI: 10.1097/PAS.0000000000002179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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