Article
Integrating Next-Generation Sequencing with Morphology Improves Prognostic and Biologic Classification of Spitz Neoplasms.
The Journal of investigative dermatology - 1 Aug 2020
Quan Victor L, Zhang Bin, Zhang Yongzhan, Mohan Lauren S, Shi Katherine, Wagner Annette, Kruse Lacey, Taxter Timothy, Beaubier Nike, White Kevin, Zou Lihua, Gerami Pedram
Abstract excerpt
The newest World Health Organization classification of skin tumors suggests the elimination of cases with BRAF and NRAS mutations from the categories of Spitz tumors (ST) and Spitz melanoma (SM). The objective of this study is to better characterize the genomics of Spitz neoplasms and assess whether the integration of genomic data with morphologic diagnosis improves classification and prognostication. We...
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