Article
A Clinicopathological Study of 29 Spitzoid Melanocytic Lesions With ALK Fusions, Including Novel Fusion Variants, Accompanied by Fluorescence In Situ Hybridization Analysis for Chromosomal Copy Number Changes, and Both TERT Promoter and Next-Generation Sequencing Mutation Analysis.
The American Journal of dermatopathology - 1 Aug 2020
Kastnerova Liubov, Martinek Petr, Grossmann Petr, Steiner Petr, Vanecek Tomas, Kyclova Jitka, Ferak Ivan, Zalud Radim, Slehobr Ondrej, Svajdler Peter, Sulc Miroslav, Bradamante Mirna, Banik Martin, Hadravsky Ladislav, Sticova Eva, Hajkova Veronika, Ptakova Nikola, Michal Michal, Kazakov Dmitry V
Abstract excerpt
ALK-fused spitzoid neoplasms represent a distinctive group of melanocytic lesions. To date, few studies addressed genetic and chromosomal alterations in these lesions beyond the ALK rearrangements. Our objective was to study genetic alterations, including ALK gene fusions, telomerase reverse transcriptase promoter (TERT-p) mutations, chromosomal copy number changes, and mutations in other genes. We investigated...
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