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Article

Toward a Molecular-Genetic Classification of Spitzoid Neoplasms.

Clinics in laboratory medicine - 1 Sept 2017

Tetzlaff Michael T, Reuben Alexandre, Billings Steven D, Prieto Victor G, Curry Jonathan L

Abstract excerpt

The histopathologic spectrum of Spitzoid neoplasms includes Spitz nevi, atypical Spitz tumors, and Spitzoid melanomas. Advances in molecular genetics have evolved to the point that Spitzoid lesions can now be reasonably classified according to their distinctive molecular-genetic alterations: Spitzoid lesions with (1) 11p amplification and/or HRAS mutations; (2) isolated loss of 6q23 by fluorescence in situ...

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Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 6
NTRK3 gene
In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28802494
DOI: 10.1016/j.cll.2017.05.003

Genes

ALK
BAP1
BRAF
HRAS
MET
NTRK1
NTRK3
RET
ROS1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Related research

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Toward a Molecular-Genetic Classification of Spitzoid Neoplasms.PMID 28802494Read ↗

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