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Article

The impact of next generation sequencing studies on the diagnosis of BAP1 inactivated melanocytic tumors.

Human pathology - 1 Jun 2026

Braat Jonathan, Trichy Nithya Sai, Holic Lindsay Jeanne, Olivares Shantel, Bahrami Armita, Balamurugan Thiagarajah, Barnhill Raymond, Blokx Willeke A M, Busam Klaus J, Cerroni Lorenzo, Cook Martin, Duncan Lyn, Elder David, Ferguson Peter, Ferrara Gerardo, Ko Jennifer, Landman Gilles, Lezcano Cecilia, Lowe Lori, Massi Daniela, Mihic-Probst Daniela, Parker Douglas, Sargen Michael, Scolyer Richard, Shea Christopher, Spatz Alan, Tetzlaff Michael, Torres-Cabala Carlos Antonio, Tron Victor, Yeh Iwei, Yun Sook Jung, Zembowicz Artur, Gerami Pedram

Abstract excerpt

BAP1 inactivated melanocytic tumors (BIMTs) are recognized for their potential for significant morphologic atypia including nuclear atypia, expansile growth, and mitotic activity, making it difficult to form firm morphologic criteria for malignancy. Next generation sequencing (NGS) is becoming increasingly utilized in melanocytic pathology. We conducted a two-phase survey with 26 dermatopathologists from the...

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Identifiers

PMID: 41831527
DOI: 10.1016/j.humpath.2026.106103
PMCID: PMC13396703

Genes

BAP1
CDKN2A
MYC
PTEN
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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