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Article

T2-DAG: a powerful test for differentially expressed gene pathways via graph-informed structural equation modeling.

Bioinformatics (Oxford, England) - 27 Jan 2022

Jin Jin, Wang Yue

Abstract excerpt

MOTIVATION: A major task in genetic studies is to identify genes related to human diseases and traits to understand functional characteristics of genetic mutations and enhance patient diagnosis. Compared with marginal analyses of individual genes, identification of gene pathways, i.e. a set of genes with known interactions that collectively contribute to specific biological functions, can provide more...

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PMID: 34755844
DOI: 10.1093/bioinformatics/btab770
PMCID: PMC8796375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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