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Article

PaIRKAT: A pathway integrated regression-based kernel association test with applications to metabolomics and COPD phenotypes.

PLoS computational biology - 1 Oct 2021

Carpenter Charlie M, Zhang Weiming, Gillenwater Lucas, Severn Cameron, Ghosh Tusharkanti, Bowler Russell, Kechris Katerina, Ghosh Debashis

Abstract excerpt

High-throughput data such as metabolomics, genomics, transcriptomics, and proteomics have become familiar data types within the "-omics" family. For this work, we focus on subsets that interact with one another and represent these "pathways" as graphs. Observed pathways often have disjoint components, i.e., nodes or sets of nodes (metabolites, etc.) not connected to any other within the pathway, which notably...

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Identifiers

PMID: 34679079
DOI: 10.1371/journal.pcbi.1008986
PMCID: PMC8565741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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