Article
The zinc finger motif of Escherichia coli RecQ is implicated in both DNA binding and protein folding.
The Journal of biological chemistry - 8 Oct 2004
Liu Jie Lin, Rigolet Pascal, Dou Shuo-Xing, Wang Peng-Ye, Xi Xu Guang
Abstract excerpt
The RecQ family of DNA helicases has been shown to be important for the maintenance of genomic integrity. Mutations in human RecQ genes lead to genomic instability and cancer. Several RecQ family of helicases contain a putative zinc finger motif of the C4 type at the C terminus that has been identified in the crystalline structure of RecQ helicase from Escherichia coli. To better understand the role of this motif...
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