Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular genetic characterization of acute myeloid leukemia with isolated trisomy of chromosomes 4, 11, and 21.

International journal of laboratory hematology - 1 Apr 2022

Zhou Feng, Shen Hongjie, Wang Zheng, Hua Haiying, Wu Pin, Han Wenmin, Xia Jia Zhu, Cai Xiaohui, Chao Hongying, Lu Xuzhang

Abstract excerpt

BACKGROUND: Autosomal trisomy is a relatively rare abnormality observed in AML, occurring singly or as a secondary event in association with other karyotypic changes, and associated with prognosis. The molecular genetic and clinical characterizations of acute myeloid leukemia (AML) with isolated trisomy 4, 11, or 21 have been poorly investigated. MATERIALS AND METHODS: Interphase fluorescence in situ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Prognosis

Share to Trisomy

Source

Identifiers

PMID: 34750981
DOI: 10.1111/ijlh.13759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular genetic characterization of acute myeloid leukemia with isolated trisomy of chromosomes 4, 11, and 21.PMID 34750981Read ↗

Molecular genetic and clinical characterization of acute myeloid leukemia with trisomy 8 as the sole chromosome abnormality.Semantic proximity Read ↗

Myeloid malignancies with acquired trisomy 21 as the sole cytogenetic change are clinically highly variable and display a heterogeneous pattern of copy number alterations and mutations.Semantic proximity Read ↗

Molecular and clinicopathologic characterization of AML with isolated trisomy 4.Semantic proximity Read ↗

Integrated Genomic and Transcriptomic Profiling of Isolated Trisomies in AML Reveals Cell Cycle Dysregulation and Therapeutic Vulnerabilities.Semantic proximity Read ↗

Isolated trisomy of chromosomes 8, 11, 13 and 21 is an adverse prognostic factor in adults with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B 8461Semantic proximity Read ↗

Trisomy 8 in acute myeloid leukemiaSemantic proximity Read ↗

Characteristics and outcome of patients with acute myeloid leukemia and trisomy 4.Semantic proximity Read ↗

GATA1 mutation analysis and molecular landscape characterization in acute myeloid leukemia with trisomy 21 in pediatric patients.Semantic proximity Read ↗

Trisomy 11 as an isolated abnormality in acute myeloid leukemia is associated with unfavorable prognosis but not with an NPM1 or KIT mutation.Semantic proximity Read ↗

High number of additional genetic lesions in acute myeloid leukemia with t(8;21)/RUNX1-RUNX1T1: frequency and impact on clinical outcome.Semantic proximity Read ↗

Trisomy 8 in pediatric acute myeloid leukemia: A NOPHO‐AML studySemantic proximity Read ↗

Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.