Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated Genomic and Transcriptomic Profiling of Isolated Trisomies in AML Reveals Cell Cycle Dysregulation and Therapeutic Vulnerabilities.

Journal of cellular and molecular medicine - 1 Nov 2025

Maués Jersey Heitor da S, Duarte Bruno Kosa L, Svidnicki Maria Carolina C M, Filho Herton Luiz A S, Niemann Fernanda Soares, Duarte Adriana da Silva S, de Melo Campos Paula, Moraes-Vieira Pedro M, Olalla Saad Sara Teresinha

Abstract excerpt

Acute myeloid leukaemia (AML) with isolated trisomies (ITs) represents a distinct cytogenetic subgroup with heterogeneous clinical behaviour and incompletely defined molecular features. To explore its genomic and transcriptomic landscape, we performed next-generation sequencing (NGS) on 14 AML patients harbouring isolated trisomies of chromosomes 8, 9, 10, 13, 14, 21 and 22. RNA sequencing (RNA-Seq) was conducted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Leukemic

Share to Genomics

Share to Leukemia, Myeloid, Acute

Share to Transcriptome

Share to Trisomy

Source

Open in PubMed Open full text

Identifiers

PMID: 41310823
DOI: 10.1111/jcmm.70941
PMCID: PMC12660057

Genes

ASXL1
BRAF
CALR
CDC25A
CDC7
DHFR
DNAJC3
DNMT3A
EGFR
HSP90B1
HSPA5
IDH1
MCM4
TET2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated Genomic and Transcriptomic Profiling of Isolated Trisomies in AML Reveals Cell Cycle Dysregulation and Therapeutic Vulnerabilities.PMID 41310823Read ↗

Molecular genetic characterization of acute myeloid leukemia with isolated trisomy of chromosomes 4, 11, and 21.Semantic proximity Read ↗

Isolated trisomy of chromosomes 8, 11, 13 and 21 is an adverse prognostic factor in adults with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B 8461Semantic proximity Read ↗

Trisomy 8 in acute myeloid leukemiaSemantic proximity Read ↗

Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosisSemantic proximity Read ↗

Molecular genetic and clinical characterization of acute myeloid leukemia with trisomy 8 as the sole chromosome abnormality.Semantic proximity Read ↗

Distinct karyotypic and mutational landscape in trisomy AML.Semantic proximity Read ↗

Mutational Profile Enables the Identification of a High-Risk Subgroup in Myelodysplastic Syndromes with Isolated Trisomy 8Semantic proximity Read ↗

A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AMLSemantic proximity Read ↗

Mutational Landscape and Clinical Outcomes in AML With Sole Trisomy 8.Semantic proximity Read ↗

Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype.Semantic proximity Read ↗

The genomic landscape of hypodiploid acute lymphoblastic leukemia.Semantic proximity Read ↗

Myeloid malignancies with acquired trisomy 21 as the sole cytogenetic change are clinically highly variable and display a heterogeneous pattern of copy number alterations and mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.