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Article

GATA1 mutation analysis and molecular landscape characterization in acute myeloid leukemia with trisomy 21 in pediatric patients.

International journal of laboratory hematology - 1 Aug 2021

Panferova Agnesa, Gaskova Marina, Nikitin Eugenyi, Baryshev Pavel, Timofeeva Natalia, Kazakova Anna, Matveev Viktor, Mikhailova Ekaterina, Popov Alexander, Kalinina Irina, Hachatrian Lili, Maschan Aleksey, Maschan Michael, Novichkova Galina, Olshanskaya Yulia

Abstract excerpt

INTRODUCTION: Accurate detection of GATA1 mutation is highly significant in patients with acute myeloid leukemia (AML) and trisomy 21 as it allows optimization of clinical protocol. This study was aimed at (a) enhanced search for GATA1 mutations; and (b) characterization of molecular landscapes for such conditions. METHODS: The DNA samples from 44 patients with newly diagnosed de novo AML with trisomy 21 were...

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Identifiers

PMID: 33386779
DOI: 10.1111/ijlh.13451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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