Article
Characteristics and outcome of patients with acute myeloid leukemia and trisomy 4.
Haematologica - 1 Jan 2023
Kayser Sabine, Martínez-Cuadrón David, Hanoun Maher, Stölzel Friedrich, Gil Cristina, Reinhardt H Christian, Aguiar Eliana, Schäfer-Eckart Kerstin, Burgues Juan Miguel Bergua, Steffen Björn, Bernal Teresa, Krause Stefan W, Riaza Rosalía, Schliemann Christoph, Cervera Jose, Kaufmann Martin, Torres-Miñana Laura, Hänel Mathias, Acuña-Cruz Evelyn, Jost Edgar, Algarra Jesus Lorenzo, Crysandt Martina, Fransecky Lars, Cornago-Navascues Javier, Kraus Sabrina, Martinez-Lopez Joaquin, Einsele Hermann, Niemann Dirk, Neubauer Andreas, Seggewiß-Bernhardt Ruth, Scholl Sebastian, Klein Stefan A, Schmid Christoph, Schaich Markus, Schmidt-Hieber Martin, Zukunft Sven, Ho Anthony D, Platzbecker Uwe, Baldus Claudia D, Müller-Tidow Carsten, Thiede Christian, Bornhäuser Martin, Serve Hubert, Levis Mark, Montesinos Pau, Röllig Christoph, Schlenk Richard F
Abstract excerpt
We retrospectively studied 125 patients with acute myeloid leukemia and trisomy 4 (median age at diagnosis, 58 years; range, 16-77 years) treated between 2000 and 2019 within a multicenter study. Trisomy 4 was the sole abnormality in 28 (22%) patients and additional abnormalities were present in 97 (78%) patients. Twenty-two (22%) and 15 (15%) of 101 tested patients harbored NPM1 and FLT3-ITD mutations. Two (3%)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.