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Article

Molecular and clinicopathologic characterization of AML with isolated trisomy 4.

American journal of clinical pathology - 1 Mar 2012

Bains Ashish, Lu Gary, Yao Hui, Luthra Rajalakshmi, Medeiros L Jeffrey, Sargent Rachel L

Abstract excerpt

Acute myeloid leukemia (AML) with isolated trisomy 4 is rare. Associations with KIT mutations on chromosome 4q12 have been documented. The clinicopathologic features and mutational status of KIT, FLT3, NPM1, CEBPA, and RAS were assessed in 13 AML cases with isolated trisomy 4. There were 9 men and 4 women with a median age of 54 years. Median blast count was 84% (range, 24%-93%). Morphologic features varied...

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Source

Identifiers

PMID: 22338050
DOI: 10.1309/AJCP7ZC9YQERSKGX

Genes

KIT
FLT3
NPM1
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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