USP8 Mutations Associated with Cushing's Disease Alter Protein Structure Dynamics.

Abstract excerpt

The adenomas in Cushing's disease frequently exhibit mutations in exon 14, within a binding motif for the regulatory protein 14-3-3 located between the catalytic domain (DUB), responsible for ubiquitin hydrolysis, and the WW-like domain that mediates autoinhibition, resulting in constantly active USP8. The exact molecular mechanism of deubiquitinase activity disruption in Cushing's disease remains unclear. To...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endopeptidases
• Share to Endosomal Sorting Complexes Required for Transport