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Article

Systemic lupus erythematosus is causally associated with hypothyroidism, but not hyperthyroidism: A Mendelian randomization study

13 Feb 2023

Abstract excerpt

Background The relationship between systemic lupus erythematosus (SLE) and thyroid diseases is still controversial. Due to confounders and reverse causation, previous studies were not convincing. We aimed to investigate the relationship between SLE and hyperthyroidism or hypothyroidism by Mendelian randomization (MR) analysis. Methods We performed a two-step analysis using bidirectional two-sample univariable and...

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PMID: 36860870
DOI: 10.3389/fimmu.2023.1125415

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