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Article

Deciphering the mediating role of CXCL10 in hypothyroidism-induced idiopathic pulmonary fibrosis in European ancestry: a Mendelian randomization study.

Frontiers in immunology - 1 Jan 2024

Xing Xiaoming, Zhao Cong, Cai Song, Wang Jing, Zhang Jing, Sun Fang, Huang Mao, Zhang Lishan

Abstract excerpt

Background: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease characterized by progressive fibrosis, leading to impaired gas exchange and high mortality. The etiology of IPF is complex, with potential links to autoimmune disorders such as hypothyroidism. This study explores the relationship between hypothyroidism and IPF, focusing on the mediating role of plasma proteins. Methods: A two-sample...

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Share to Chemokine CXCL10
Share to CXCL10 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Hypothyroidism

Share to Idiopathic Pulmonary Fibrosis

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 39185418
DOI: 10.3389/fimmu.2024.1379480
PMCID: PMC11341476

Genes

CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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