Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATRX loss inhibits DDR to strengthen radio-sensitization in p53-deficent HCT116 cells

4 Jan 2025

Abstract excerpt

Identifying novel targets for molecular radiosensitization is critical for improving the efficacy of colorectal cancer (CRC) radiotherapy. Alpha-thalassemia/mental retardation X-linked (ATRX), a member of the SWI/SNF-like chromatin remodeling protein family, functions in the maintenance of genomic integrity and the regulation of apoptosis and senescence. However, whether ATRX is directly involved in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to RNA regulation and disease
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39755758
DOI: 10.1038/s41598-024-85085-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATRX loss inhibits DDR to strengthen radio-sensitization in p53-deficent HCT116 cellsPMID 39755758Read ↗

Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivitySemantic proximity Read ↗

Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastomaSemantic proximity Read ↗

Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal CancerSemantic proximity Read ↗

ATRX, a guardian of chromatinSemantic proximity Read ↗

From pathology to therapy: A comprehensive review of ATRX mutation related molecular functions and disorders.Semantic proximity Read ↗

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancerSemantic proximity Read ↗

Novel Cellular Functions of ATR for Therapeutic Targeting: Embryogenesis to TumorigenesisSemantic proximity Read ↗

LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancerSemantic proximity Read ↗

PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancerSemantic proximity Read ↗

The Chromatin Remodeler ATRX: Role and Mechanism in Biology and CancerSemantic proximity Read ↗

G-quadruplex stabilizer CX-5461 effectively combines with radiotherapy to target α-thalassemia/mental retardation X-linked-deficient malignant gliomaSemantic proximity Read ↗

ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.