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Pan-cancer Analysis of Homologous Recombination Repair-associated Gene Alterations and Genome-wide Loss-of-Heterozygosity Score.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2022

Westphalen C Benedikt, Fine Alexander D, André Fabrice, Ganesan Shridar, Heinemann Volker, Rouleau Etienne, Turnbull Clare, Garcia Palacios Luis, Lopez Jorge-Antonio, Sokol Ethan S, Mateo Joaquin

Abstract excerpt

PURPOSE: To study associations across tumor types between genome-wide loss of heterozygosity (gLOH) and alterations in homologous recombination repair (HRR)-associated genes beyond BRCA1 and BRCA2. EXPERIMENTAL DESIGN: Genomic profiling using a targeted next-generation sequencing assay examining 324-465 genes (FoundationOne, FoundationOne Heme, and FoundationOne CDx; Foundation Medicine, Inc.) was performed in a...

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Identifiers

PMID: 34740923
DOI: 10.1158/1078-0432.CCR-21-2096
PMCID: PMC8982267

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