Article
Loss of FBXW7 Correlates with Increased IDH1 Expression in Glioma and Enhances IDH1-Mutant Cancer Cell Sensitivity to Radiation.
Cancer research - 1 Feb 2022
Yang Zhuo, Hu Nan, Wang Weiwei, Hu Weihua, Zhou Shaolong, Shi Jianxiang, Li Minghe, Jing Zhou, Chen Chao, Zhang Xuyang, Yang Ruyi, Fu Xudong, Wang Xinjun
Abstract excerpt
F-box and WD repeat domain containing 7 (FBXW7) is a substrate receptor of the ubiquitin ligase SKP1-Cullin1-F-box complex and a potent tumor suppressor that prevents unregulated cell growth and tumorigenesis. However, little is known about FBXW7-mediated control of cell metabolism and related functions in cancer therapy. Here, we report that FBXW7 expression inversely correlates with the expression levels of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.