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Article

RIPPLY1 suppresses cancer cell stemness via targeting TBX19 in CTNNB1 -mutated hepatocellular carcinoma.

Hepatology (Baltimore, Md.) - 1 Jul 2026

Zhangyuan Guangyan, Yu Weiwei, Tian Wenfang, Xie Junjie, Wang Jun, Ying Xiayang, Wang Fei, Shao Yufei, Tan Xiuxiang, Qian Hao, Deng Yexuan, Shen Baiyong

Abstract excerpt

BACKGROUND AND AIMS: CTNNB1 -mutated HCCs exhibit a relatively low stem-like and well-differentiated phenotype. However, the mechanism remains unclear. Ripply transcriptional repressor 1 (RIPPLY1), a transcriptional repressor required for somite segmentation, has hardly been studied in cancer. Here, we aim to unveil the role of RIPPLY1 in the regulation of cancer cell stemness in CTNNB1 -mutated HCCs. APPROACH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40901752
DOI: 10.1097/HEP.0000000000001483

Genes

RIPPLY1
CTNNB1
TBX19
TLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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