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Article

Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation

12 Oct 2018

Abstract excerpt

RASSF1A (Ras association domain family 1 isoform A) is a tumor suppressor and frequently inactivated by promoter hypermethylation in hepatocellular carcinoma (HCC). Autophagy is to degrade misfolded or aggregated proteins and dysfunctional organelles. Autophagy defects enhance oxidative stress and genome instability to promote tumorigenesis. Activating autophagy flux by increasing levels of the...

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PMID: 30315205
DOI: 10.1038/s41418-018-0211-7

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