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Article

Prognostic significance of in patients with chronic lymphocytic leukemia: A meta-analysis.

Annals of hematology - 1 Aug 2025

Huang Liping, Shi Xinyi, Tang Ningning, Liu Juan, Liang Yanli, Wang Xin

Abstract excerpt

NOTCH1 and SF3B1 mutations are common in CLL, but their prognostic value for overall survival (OS) and progression-free survival (PFS), as well as time to first treatment (TTFT) and treatment-free survival (TFS), remains uncertain. This meta-analysis systematically evaluates their impact. A systematic search of PubMed, Embase, Cochrane Library, and Web of Science was performed up to March 2025. Relevant study...

Read the complete abstract on PubMed

Topics

Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Receptor, Notch1
RNA Splicing Factors
Prognosis
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phosphoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 40736550
DOI: 10.1007/s00277-025-06499-4
PMCID: PMC12431906

Genes

NOTCH1
SF3B1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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