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[Gene atm and chronic lymphocytic leukemia - review].

Zhongguo shi yan xue ye xue za zhi - 1 Oct 2008

Zhu Dan-Xia, Xu Wei, Li Jian-Yong

Abstract excerpt

The ataxia telangiectasia mutated gene (atm) is a tumor-suppressing gene, locates in the human chromosome 11q22-23. This gene mainly participates in recognition and repairment of DNA damage and plays a critical role in signal transduction pathway induced by double strand breaks (DSB). In chronic lymphocytic leukemia (CLL) there is high frequency of loss of heterozygosity (LOH) and mutation of atm gene, which...

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Identifiers

PMID: 18928637

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