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Article

Morphological and sensorimotor phenotypes in a zebrafish CHARGE syndrome model are domain-dependent.

Genes, brain, and behavior - 1 Jun 2023

Hodorovich Dana R, Lindsley Patrick M, Berry Austen A, Burton Derek F, Marsden Kurt C

Abstract excerpt

CHARGE syndrome is a heterogeneous disorder characterized by a spectrum of defects affecting multiple tissues and behavioral difficulties such as autism, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, anxiety, and sensory deficits. Most CHARGE cases arise from de novo, loss-of-function mutations in chromodomain-helicase-DNA-binding-protein-7 (CHD7). CHD7 is required for processes such as...

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PMID: 36717082
DOI: 10.1111/gbb.12839
PMCID: PMC10242184

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